Pharmacokinetics of oral morphine and pharmacogenomics of CYP2D6 and UGT2B7, in an urban pediatric population (2 – 6 years of age) presenting for elective surgery – Phase 1

This study will help us to identify and collect samples from children who have taken a single oral dose of the pain medication morphine, and to determine the genetic differences in the way children metabolize (break down in the body and how it affects them) morphine.

Who can participate in this study?

• Your child is eligible for this study if they are between 2 and 6 years old and are generally healthy, having a procedure that requires opioid pain medication and will be staying at the hospital for at least 4 hours. The investigators will determine your child’s eligibility.

Who should not participate in this study?

• Your child must not have an allergy or previous reaction to morphine, any indication that they cannot have morphine pain medication, abnormal liver or kidney function, current regular use of any opioids, any indication that they cannot receive an oral pre-medication and cannot be under or overweight.

Status?

• Actively recruting subjects.

For more information, please see the Consent/Information form